Advances in Nod-like receptors (NLR) biology

The innate immune system is equipped with a set of receptors, termed pattern recognition receptors (PRRs), that detect imminent dangers such as microbial invasion, environmental or endogenous noxious substances, and elicit protective responses to contain and eliminate these harmful triggers while providing the host with resistance mechanisms to tolerate damage and restore normalcy. PRRs can be classified into five main classes that include Toll-like receptors (TLRs), nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs), retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), absent-in-melanoma (AIM)-like receptors (ALRs) and C-type lectins (CTLs).
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research