Danger, diversity and priming in innate antiviral immunity

The rapid response to viral infection is imperative for a cell, tissue and whole organism to gain the advantage in the interplay between host and virus. In the traditional model, viral infection is first detected via pattern recognition receptors (PRRs). At the cell surface, detection can be mediated following recognition of viral glycoproteins by surface receptors such as Toll-like receptors (TLRs) [1–3]. Following entry, viral nucleic acids act as pathogen associated molecular patterns (PAMPs) and are recognized via TLRs in the endosome or RIG-I-like receptors (RLRs) or DNA sensors in the cytoplasm.

Source: Cytokine and Growth Factor Reviews - July 11, 2014 Category: Molecular Biology Authors: Susan E. Collins, Karen L. Mossman Tags: Mini review Source Type: research