IL-12-and IL-23 in health and disease

The interleukin 12 (IL-12) cytokine family includes IL-12, IL-23, IL-27 and its most recent member, IL-35. Each cytokine is formed of two subunits, some of which form bioactive cytokines themselves, and others which are shared among family members. Such a characteristic provides these cytokines with a great degree of interaction potential not present in other cytokine families, both in the context of receptor binding and other molecular interactions. This diversity is perhaps responsible for the highly variable biological functions that have been reported in the context of preclinical studies of inflammation.

Source: Cytokine and Growth Factor Reviews - July 31, 2014 Category: Molecular Biology Authors: Andrew L. Croxford, Paulina Kulig, Burkhard Becher Tags: Mini review Source Type: research