An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders

Recently, growing evidence has demonstrated that nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal regulator of endogenous defense systems that function via the activation of a set of protective genes, and this is particularly clear in the central nervous system (CNS). Therefore, it is highly useful to summarize the current literature on the molecular mechanisms and role of Nrf2 in the CNS. In this review, we first briefly introduce the molecular features of Nrf2. We then discuss the regulation, cerebral actions, upstream modulators and downstream targets of Nrf2 pathway.

Source: Cytokine and Growth Factor Reviews - September 14, 2014 Category: Molecular Biology Authors: Yang Yang, Shuai Jiang, Juanjuan Yan, Yue Li, Zhenlong Xin, Yan Lin, Yan Qu Tags: Mini review Source Type: research