Vitamin C for the critically ills: is the evidence strong enough?

Adequate intake of vitamin C is of uttermost importance in humans considering that, similarly to most other mammals, humans lack the L-gulonolactone oxidase required for its production. Adequate plasma levels are therefore dependent on sufficient vitamin C intake and adequate absorption by the intestinal sodium-dependant vitamin C transporter (SVCT1) [1]. As a water-soluble vitamin, it is filtrated in kidney by the glomerulus and is reabsorbed in the proximal tubule. This reabsorption is critical in case of deficiency to minimize renal loss.
Source: Nutrition - Category: Nutrition Authors: Tags: Review Source Type: research