Pituitary pars intermedia dysfunction does not necessarily impair insulin sensitivity in old horses

The objective of the study was to determine if aged horses with PPID had reduced insulin sensitivity and alterations in the insulin-mediated signaling pathways in the skeletal muscle when compared with healthy aged horses. Isoglycemic hyperinsulinemic clamp procedures were conducted in 12 horses that were classified as either PPID (n = 6; age: 25.0 ± 2.5 yr; mean ± standard deviation) or non-PPID, aged-matched controls (control) (n = 6; age: 25.7 ± 2.0 yr).

Source: Domestic Animal Endocrinology - August 1, 2014 Category: Endocrinology Authors: L.M. Mastro, A.A. Adams, K.L. Urschel Source Type: research