Examining the influence of PTH(1-34) on tissue strength and composition

The lacunar-canaliculi system is a network of channels that is created and maintained by osteocytes as they are embedded throughout cortical bone. As osteocytes modify their lacuna space, the local tissue composition and tissue strength are subject to change. Although continual exposure to parathyroid hormone (PTH) can induce adaptation at the lacunar wall, the impact of intermittent PTH treatment on perilacunar adaptation remains unclear. Therefore, the primary objective of this study was to establish how intermittent PTH(1-34) treatment influences perilacunar adaptation with respect to changes in tissue composition.

Source: Bone - September 24, 2018 Category: Orthopaedics Authors: Joseph D. Gardinier, Salam Al-Omaishi, Niloufar Rostami, Michael D. Morris, David H. Kohn Tags: Full Length Article Source Type: research