Loss of Gs α in osteocytes leads to osteopenia due to sclerostin induced suppression of osteoblast activity

In this study, we have examined the role of Gsα in osteocytes, the terminally differentiated and most abundant cells of the osteoblast lineage. Mice lacking the stimulatory subunit of G-proteins (Gsα) in osteocytes (DMP1-GsαKO) have significant decrease of both trabecular and cortica l bone, as assessed by μCT.
Source: Bone - Category: Orthopaedics Authors: Tags: Full Length Article Source Type: research