Impairments in reversal learning following short access to cocaine self-administration

Cocaine addiction is a chronic relapsing disease that is characterized by drug craving and loss of inhibitory control (Jentsch and Taylor, 1999). A major challenge in the successful treatment of cocaine addiction is reducing the risk of relapse, which remains high after months or even years of abstinence (Dackis and O ’Brien, 2001; Mendelson and Mello, 1996). Concomitant with a high risk of relapse, cocaine addicts also display cognitive deficits in the domain of reversal learning (Ersche et al., 2008).

Source: Drug and Alcohol Dependence - October 1, 2018 Category: Addiction Authors: Allison R. Bechard, Amber LaCrosse, Mark D. Namba, Brooke Jackson, Lori A. Knackstedt Tags: Full length article Source Type: research