PubChem added Gene Ontology (GO) in BioAssay summary
The PubChem BioAssay summary pages now display the Gene Ontology (GO) classification of the
gene/protein target(s) that were tested by the bioassay. The GO terms are
associated with each gene/protein in an automated way as part of the biosystems
database data processing procedures, using the method
described in the Biosystems help document. All GO terms that apply to the
gene(s)/protein(s) tested by the bioassay are shown in the GO hierarchy,
including: (1) biological processes, (2) cellular components, and (3) molecular
functions. Clicking on any GO term in the hierarchy will retrieve all bioassays
that have tested a protein(s) associated with that term. As an example, see the
GO terms for the protein target that was tested by the glucocorticoid receptor
(GR) redistribution assay (AID
450).In addition, the PubChem BioAssay data summary for a compound
now displays a graphical summary of the bioassays that have tested the compound,
categorizing the bioassays by: (1) bioactivity outcomes (active, inactive,
inconclusive, unspecified); (2) top targets; (3) bioactivity types (IC50, EC50,
Potency, Ki, etc.); (4) bioassay types (screening, confirmatory, summary,
other). The bar graphs are clickable and serve as filters to display data from
the selected category, refreshing both the bar graphs and the tabular summary of
bioassays to reflect the data subset you have selected. As an example, see the
bioassay data summary for aspirin (CID
2244).
Source: PubChem News - Category: Chemistry Authors: Pubchem Source Type: news