Allen M, Nietlisbach N, Johnson RA. Evaluation of self-injurious behavior, food intake, fecal output, and thermal withdrawal latencies after injection of a high-concentration buprenorphine formulation in rats (Rattus norvegicus). Am J Vet Res 79(2):154 ‒162, 2018.

The current recommended dose of buprenorphine hydrochloride in rats is 0.05 mg/kg subcutaneously (SC) or intravenously (IV) every 6 to 12 hours. Repeated injections often predispose rats to signs consistent with stress, decreased food intake and weight gain, altered activity, and heightened sensitivity to pain stimuli (hyperalgesia). Adverse effects of buprenorphine administration can also include a slow-down in gastrointestinal function, pica, and opioid tolerance. Self-biting, cage biting, and other stereotypic behavior have been reported in rats after administration of other opioids.

Source: Journal of Exotic Pet Medicine - October 1, 2018 Category: Veterinary Research Source Type: research