Facile Synthesis of PEGylated Tungsten-based Nanoprobes for Gastric Computed Tomography Imaging

Publication date: October 2018Source: Chinese Journal of Analytical Chemistry, Volume 46, Issue 10Author(s): Tian-Qi ZHANG, Xue-Li HAN, Yang-Yang HE, Xiao-Jing HE, Jian-Qiu WANG, Qing-Hai YUAN, Jian-Hua LIUAbstractWith the development of science and technology, PEGylated nanoprobes have attracted a great deal of interest in the molecular imaging area of modern medicine. These nanoprobes play an important role especially in diagnosis of gastric diseases. The transition metal oxides as gastric contrast agents based on PEGylated WO3−x nanoprobes were designed in this work. The nanoprobes were developed via a high-temperature solvent thermal method, and then modified with polyethylene glycol (PEG) to improve stability and dispersivity of nanoprobes in water. The characterizations of PEGylated WO3−x nanoprobes included scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopy analysis etc. Moreover, in vivo toxicological studies were carried out with histopathology. Otherwise, as a contrast agent, multi-slice computed tomography (MDCT) imaging were illustrated both in vitro and in vivo assessment. The results indicated that PEGylated WO3−x nanoprobes had great potential for gastric MDCT imaging in detection of gastric diseases.Graphical abstractPEGylated nanoprobes have attracted a great deal of interest in the area of molecular imaging area along with the rapid develo...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research