Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate

This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45  mL of vehicle (VEH and VEH/aPDT) or 0.45 mL of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively.

Source: Bone - October 16, 2018 Category: Orthopaedics Authors: Edilson Ervolino, Cristian Statkievicz, Luan Felipe Toro, Jo ão Martins de Mello-Neto, Thamires Priscila Cavazana, João Paulo Mardegan Issa, Rita Cássia Menegati Dornelles, Juliano Milanezi de Almeida, Maria José Hitomi Nagata, Roberta Okamoto, Cláud Tags: Full Length Article Source Type: research