Effect of topical tranexamic acid on reducing blood loss in primary total knee arthroplasty in Southern Chinese population

The objective of this study was to evaluate the efficacy of topical tranexamic acid (TA) on the postoperative blood loss and transfusion rate after primary total knee arthroplasty (TKA). Two hundred ninety-six patients (n = 296) undergoing TKA in Pok Oi Hospital were included in this study from July 2015 to September 2016. The topical TA group (n =154) showed a significant reduction in haemoglobin drop (2.76 g/dL vs. 3.62 g/dL, p < 0.001), haematocrit drop (0.0876 vs. 0.112, p < 0.001), transfusion rate (3.2% vs. 23.9%, p < 0.001), drain output (199 mL vs. 276 mL, p < 0.001) and length of stay (9 days vs. 11 days, p < 0.001) compared with those in the control group (n = 142). There was no thromboembolic complication associated with TA use. The results supported the use of topical TA to control postoperative blood loss after TKA.中文摘要本研究的目的主要是評估氨甲環酸 (TA) 局部注射對於全人工膝關節置換術後失血量及輸血需求的影響。在2015年7月至2016年9月期間，296 名患者在博愛醫院接受了初次全人工膝關節置換術。 結果顯示氨甲環酸局部注射有效減低了血紅蛋白(2.76 g/dL vs. 3.62 g/dL, p < 0.001) 、血细胞比容 (0.0876 vs. 0.112, p < 0.001)、輸血率(3.2% vs. 23.9%, p < 0.001)、引流輸出量 (199 mL vs. 276 mL, p < 0.001) 及住院日數 (9 日vs.11 日, p < 0.001)。氨甲環酸局部注射的使用和血栓性栓塞併發症...
Source: Journal of Orthopaedics, Trauma and Rehabilitation - Category: Orthopaedics Source Type: research