Qualitative and semi-quantitative analysis of health-care pharmaceutical products using laser-induced breakdown spectroscopy

Publication date: Available online 15 October 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Sobia Nisar, Ghulam Dastgeerb, Muhammad Shafiqa, Muhammad UsmanAbstractLaser-induced breakdown spectroscopy (LIBS) is a sensitive optical technique that is capable of rapid multi-elemental analysis. The development of this technique for elemental analysis of pharmaceutical products may eventually revolutionize the field of human health. Under normal circumstances, the elemental analysis of pharmaceutical products based on chemical methods is time-consuming and complicated. In this investigation, the principal aim is to develop a LIBS-based methodology for elemental analysis of pharmaceutical products. This LIBS technique was utilized for qualitative as well as quantitative analysis of the elements present in calcium-based tablets. All the elements present in the tablets were detected and their percentage compositions were verified in a single shot, using the proposed instrument. These elements (e.g., Ca, Mg, Fe, Zn, and others) were identified by the wavelength of their spectral lines, which was verified using the NIST database. The approximate amount of each element was determined based on their observed peaks and the result was in exact agreement with the content specification. The determination of the composition of prescription drug for patients is highly important in numerous circumstances. For example, the exploitation of LIBS may facilitate elemental decomposition of ...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research