Automated radiosynthesis of 5-[11C]l-glutamine, an important tracer for glutamine utilization

The natural amino acid l-Glutamine (Gln) is essential for both cell growth and proliferation. In addition to glucose, cancer cells utilize Gln as a carbon source for ATP production, biosynthesis, and as a defense against reactive oxygen species. The utilization of [11C]Gln has been previously reported as a biomarker for tissues with an elevated demand for Gln, however, the previous reports for the preparation of [11C]Gln were found to be lacking several crucial aspects necessary for transition to human production.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research