Thrombin generation in patients with severe thermal injury

In patients with severe burn, changes in hemostasis result from trauma itself (e.g. tissue hypoperfusion, hypothermia, altered platelet function, systemic inflammatory response) and from therapeutic interventions (e.g. hemodilution, blood loss due to wound excision) [1 –4]. Results of conventional coagulation assays measured in daily clinical practice [e.g. prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), low platelet count] are often interpreted as coagulopathy implying a bleeding tendency [5].

Source: Burns : Journal of the International Society for Burn Injuries - October 13, 2018 Category: Cosmetic Surgery Authors: Marion Wiegele, Eva Schaden, Stefan Koch, Daniel Bauer, Christoph Krall, Dieter Adelmann Source Type: research