HPV genotyping and E6/E7 transcript assays for cervical lesion detection in an Asian Screening Population – Cobas and Aptima HPV tests

Persistent hrHPV infection has been established as a necessary oncogenic factor for cervical carcinogenesis [1]. Globally, cervical cancer remains one of the most deadly malignancies in women but its incidence is highly reducible by screening, HPV vaccination and education. Screening for cancerous and precancerous cervical lesions has been performed through morphological examination of cervical cytology (pap smear). Detection of hrHPV in cervical sample is emerging as the molecular test for cervical cancer screening and for triage of cases with equivocal pap smear.
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research