Aberrant expression of membranous carbonic anhydrase IX (CAIX) is associated with unfavorable disease course in papillary and clear cell renal cell carcinoma

Carbonic anhydrases constitute a large family of transmembrane zinc metalloenzymes catalyzing hydration of carbonic dioxide to form bicarbonate and hydrogen ions (reviewed in [1]). Carbonic anhydrases play a pivotal role in tissue pH homeostasis [2]. They have further been shown to play a role in the regulation of cell adhesion [3], and they are required for cellular growth and survival under normoxia and hypoxia [4,5]. It is probably because of this later function, that carbonic anhydrase 9 (CAIX) is often deregulated in cancer.

Source: Urologic Oncology: Seminars and Original Investigations - October 12, 2018 Category: Urology & Nephrology Authors: Franziska B üscheck, Christoph Fraune, Ronald Simon, Martina Kluth, Claudia Hube-Magg, Christina Möller-Koop, Navid Shadanpour, Clemens Bannenberg, Christian Eichelberg, Doris Höflmayer, Till Clauditz, Corinna Wittmer, Waldemar Wilczak, Guido Sauter, M Tags: Original article Source Type: research