Genomic path to pandrug resistance in a clinical isolate of Klebsiella pneumoniae

Carbapenem-resistant Klebsiella pneumoniae have spread through tertiary hospitals worldwide during the last decades [1]. Some sequence types (STs) have been particularly successful, causing outbreaks in clinical settings and leading to endemic situations with hundreds of affected patients [2]. Over the years, antimicrobial pressure has led to the rise and dissemination of strains with increased resistance spectra. These strains have been called multidrug-resistant (MDR) when more than three antimicrobial families are affected, or extensively drug-resistant (XDR) when only one or two antimicrobial families remain active.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research