Molar activity – the keystone in 11C-radiochemistry: an explorative study using the gas phase method

Radiochemists/radiopharmacists, involved in the preparation of radiopharmaceuticals are regularly confronted with the requirement of continuous high quality productions in their day-to-day business. One of these requirements is high specific or molar activity of the radiotracer in order to avoid e.g. receptor saturation and pharmacological or even toxic effects of the applied tracer for positron emission tomography. In the case of 11C-labelled radiotracers, the reasons for low molar activity are manifold and often the search for potential 12C-contaminations is time-consuming.

Source: Nuclear Medicine and Biology - October 12, 2018 Category: Nuclear Medicine Authors: Verena Pichler, Thomas Zenz, C écile Philippe, Chrysoula Vraka, Neydher Berrotéran-Infante, Sarah Pfaff, Lukas Nics, Marius Ozenil, Oliver Langer, Matthäus Willeit, Tatjana Traub-Weidinger, Rupert Lanzenberger, Markus Mitterhauser, Marcus Hacker, Wolfg Source Type: research