Application of induced pluripotent stem cell technology for the investigation of hematological disorders

Publication date: Available online 10 October 2018Source: Advances in Biological RegulationAuthor(s): Hamid Dolatshad, Dharamveer Tatwavedi, Doaa Ahmed, Jana F. Tegethoff, Jacqueline Boultwood, Andrea PellagattiAbstractInduced pluripotent stem cells (iPSCs) were first described over a decade ago and are currently used in various basic biology and clinical research fields. Recent advances in the field of human iPSCs have opened the way to a better understanding of the biology of human diseases.Disease-specific iPSCs provide an unparalleled opportunity to establish novel human cell-based disease models, with the potential to enhance our understanding of the molecular mechanisms underlying human malignancies, and to accelerate the identification of effective new drugs. When combined with genome editing technologies, iPSCs represent a new approach to study single or multiple disease-causing mutations and model specific diseases in vitro. In addition, genetically corrected patient-specific iPSCs could potentially be used for stem cell based therapy. Furthermore, the reprogrammed cells share patient-specific genetic background, offering a new platform to develop personalized therapy/medicine for patients.In this review we discuss the recent advances in iPSC research technology and their potential applications in hematological diseases. Somatic cell reprogramming has presented new routes for generating patient-derived iPSCs, which can be differentiated to hematopoietic stem cells an...
Source: Advances in Biological Regulation - Category: Biology Source Type: research