Emergence of unusual vanA/vanB2 genotype in a highly mutated vanB2-vancomycin-resistant hospital-associated E. faecium background in Vietnam

The clinical significance of hospital associated-vancomycin resistant Enterococcus faecium (HA-VREf) and the spread by cross-contamination leading to local outbreaks is a great concern [1,2,3]. This bacteria was recently included in the seven “ESKAPE” nosocomial bacteria under global surveillance [4]. The HA-VREf originates from a specific vancomycin-susceptible E. faecium (VSEf) subpopulation, characterized by ampicillin resistance (HA-AREf) [2,5] and the carriage of IS16 [6] insertion sequence, which enables an enhanced genetic pla sticity and an easier acquisition of mobile genetic elements (MGE), vehicles of antimicrobial resistance genes [7].

Source: International Journal of Antimicrobial Agents - July 15, 2018 Category: Drugs & Pharmacology Authors: Antonella Santona, Elisa Taviani, Hoa Minh Hoang, Maura Fiamma, Massimo Deligios, Tram Viet Q Ngo, An Van Le, Pietro Cappuccinelli, Salvatore Rubino, Bianca Paglietti Source Type: research