Quasispecies dynamics and clinical significance of HCV antiviral resistance

Genetic variation of RNA viruses is a major problem for the prevention and control of the diseases they produce. Mutants resistant to antiviral inhibitors have been reported for virtually any pathogenic virus for which they have been searched such as human immunodeficiency virus type 1, human influenza virus, hepatitis B virus, etc. More recently, HCV has joined the list of viruses showing antiviral resistance due to the selection of drug-escape mutants in the course of antiviral treatments [1].

Source: International Journal of Antimicrobial Agents - October 10, 2018 Category: Drugs & Pharmacology Authors: Celia Perales Source Type: research