Immunohistochemical distinction of ABC and GCB in extranodal DLBCL is not reflected in mutation patterns

Diffuse large B cell lymphoma (DLBCL) is the most frequent form of adult lymphoma, accounting for 30-40% of diagnoses of Non Hodgkin-Lymphoma worldwide. The entity, however, is not homogenous and consists of biologically and clinically distinct subtypes. Gene expression profiling (GEP) has demonstrated at least two different types of DLBCL with distinct cells of origin. According to the gene expression patterns one type has been identified as activated B cell-like (ABC) and another as germinal center B cell-like (GCB) [1].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research