Assessing antimicrobial stewardship initiatives: Clinical evaluation of cefepime or piperacillin/tazobactam in patients with bloodstream infections secondary to AmpC-producing organisms

The increasing threat of antimicrobial resistance amongst Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. identified in healthcare-associated infections is a grave public-health concern [1]. Among the Enterobacteriaceae, AmpC β-lactamases present a unique challenge. Commonly found on chromosomes and plasmids in Enterobacter spp., Serratia spp., P. aeruginosa, Acinetobacter spp. and Citrobacter spp., their presence raises concern due to rapid hydrolysis of commonly used antimicrobial agents such as penicillins, second- a nd third-generation cephalosporins, and monobactams [2,3].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research