Correlation of preoperative Von Willebrand Factor with MRI perfusion and permeability parameters as predictors of prognosis in glioblastoma

Angiogenesis has been shown to be strictly related to tumor malignancy. Glioblastoma (GBM) is highly vascularized and von Willebrand Factor (VWF) plays a potent pro-angiogenic role. Dynamic contrast enhanced (DCE-) and dynamic susceptibility contrast (DSC-) MRI represent a widely accepted method to assess GBM microvasculature. Our aim was to investigate the correlation between plasma VWF:Ag, permeability and perfusion MRI parameters, and examine their potential in predicting GBM patient prognosis.

Source: World Neurosurgery - October 9, 2018 Category: Neurosurgery Authors: Stefania Elena Navone, Fabio Martino Doniselli, Paul Summers, Laura Guarnaccia, Paolo Rampini, Marco Locatelli, Rolando Campanella, Giovanni Marfia, Antonella Costa Tags: Original article Source Type: research