Interferon and tumor necrosis factor as humoral mechanisms coupling hematopoietic activity to inflammation and injury

Enhanced hematopoiesis accompanies systemic responses to injury and infection. Tumor necrosis factor (TNF) produced by injured cells and interferons (IFN) secreted by inflammatory cells are co-products of the process of clearance of debris and removal of still viable but dysfunctional cells. Concomitantly, these cytokines induce hematopoietic stem and progenitor cell (HSPC) activity as an intrinsic component of the systemic response. The proposed scenario includes induction of HSPC activity by type I (IFNα/β) and II (IFNγ) receptors within the quiescent bone marrow niches rendering progenitors responsive to additional signals.

Source: Blood Reviews - September 13, 2014 Category: Hematology Authors: Nadir Askenasy Tags: REVIEW Source Type: research