De novo thrombotic microangiopathy after non-renal solid organ transplantation

This article presents the first literature review on TMA following non-renal solid organ transplantation (SOT). Ischemia–reperfusion, immunosuppressive drugs, acute interfering disease and a relative deficiency of the von Willebrand factor (vWF) cleaving protease (ADAMTS13) appear to play a major role in its pathogenesis. De novo TMA occurs in 4.0% of liver and 2.3% of lung transplant recipients, whereas the incidence remains unknown after intestinal transplantation.
Source: Blood Reviews - Category: Hematology Authors: Tags: REVIEW Source Type: research