Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside

Transfusion-related acute lung injury (TRALI) is a major cause of transfusion-related mortality. Causative factors are divided in antibody mediated TRALI and non-antibody mediated TRALI. Antibody mediated TRALI is caused by passive transfusion of cognate antibodies and non-antibody mediated TRALI is caused by transfusion of aged cellular blood products. This review focuses on mechanisms in non-antibody mediated TRALI which includes soluble mediators accumulating during storage of red blood cells (RBCs) and platelets (PLTs), as well as changes in morphology and function of aged PLTs and RBCs.

Source: Blood Reviews - September 19, 2014 Category: Hematology Authors: Anna L. Peters, Maike E. van Hezel, Nicole P. Juffermans, Alexander P.J. Vlaar Tags: REVIEW Source Type: research