All in The Family: Clueing Into The Link Between Metabolic Syndrome and Hematologic Malignancies

Metabolic syndrome constitutes a constellation of findings including central obesity, insulin resistance/type 2 diabetes mellitus (DM), dyslipidemia and hypertension. Metabolic syndrome affects 1 in 4 adults in the United States and is rapidly rising in prevalence, largely driven by the dramatic rise in obesity and insulin resistance/DM. Being central to development of metabolic syndrome and its other related diseases, much focus has been placed on identifying the mitogenic effects of obesity and insulin resistance/DM as mechanistic clues of the link between metabolic syndrome and cancer.

Source: Blood Reviews - September 25, 2014 Category: Hematology Authors: Reem Karmali, Andrew Dalovisio, Jeffrey A. Borgia, Parameswaran Venugopal, Brian W. Kim, Kelly Grant Szymanski, Parameswaran Hari, Hillard Lazarus Tags: Review Source Type: research