Isolevuglandins and Cardiovascular Disease

Publication date: Available online 5 October 2018Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Sean S Davies, Linda S. May-ZhangAbstractIsolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research