The Immune-metabolic Regulatory Roles of Epoxyeicosatrienoic Acids on Macrophages Phenotypic Plasticity in Obesity-related Insulin Resistance

Publication date: Available online 5 October 2018Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Meiyan Dai, Lujin Wu, Ling Tu, Xizhen Xu, Dao Wen WangAbstractMacrophages in adipose tissue are associated with obesity-induced low-grade inflammation, which contributed to insulin resistance and the related metabolic diseases. Macrophages display phenotypic plasticity, and polarize under the condition of obesity. Epoxyeicosatrienoic Acids (EETs) are lipid mediators that are involved in the regulation of inflammatory cascades and glucose homeostasis. In this mini-review, we briefly summarize the macrophages recruitment, infiltration and polarization in obese mice, and also discuss the immune- metabolic regulatory role of EETs in this process (See Fig. 1).
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research