Disentangling the Association of Depression on the Anti-fatigue Effects of Ketamine

Fatigue and depression are complex constructs, but their association is well documented (Bakshi et al., 2000; Jacobsen et al., 2003; Brown& Kroenke, 2009). Both significantly influence the capacity to perform everyday actions and endorse greater functional disability (Lin et al., 2013; Milanovic et al., 2018). They have been strongly correlated in multiple reports (Bakshi et al., 2000; Jacobsen et al., 2003; Brown& Kroenke, 2009). However, some evidence suggests that depression and fatigue are distinct constructs, for example, it was observed that fatigue symptoms persist even after the remission of depression (Ferguson et al., 2014).

Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Leorey N. Saligan, Cristan Farmer, Elizabeth D. Ballard, Bashkim Kadriu, Carlos A. Zarate Tags: Research paper Source Type: research