Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically patients with sepsis

Severe sepsis and septic shock account for a significant proportion of admissions to ICU and are a leading cause of mortality in the critically ill [1]. Early treatment with appropriate antimicrobial therapy is an important determinant of survival. However, conventional dosing strategies consistently fail to achieve therapeutic exposures in plasma due to altered drug clearance and volume of distribution in many critically ill patients [2 –4]. Further, the effect of critical illness on antimicrobial concentrations in the interstitial fluid (ISF) of tissues, the focus of most infections, is poorly understood [5,6].

Source: International Journal of Antimicrobial Agents - October 5, 2018 Category: Drugs & Pharmacology Authors: Jacob Abraham, Mahipal Sinollareddy, Michael S. Roberts, Patricia Williams, Sandra L. Peake, Jeffrey Lipman, Jason A. Roberts Source Type: research