Buried in PEAT--discovery of a new silencing complex with opposing activities

Posttranslational histone modifications serve critical roles in gene regulation by determining the functional status of chromatin. Histone-modifying enzymes often work in large multiprotein complexes. A paper in this issue of The EMBO Journal describes a new chromatin-modifying complex called PEAT that acts via histone deacetylation. The PEAT complex is involved in heterochromatin formation and gene repression but also appears to have a locus-specific activating role, possibly through promoting histone acetylation.

Source: EMBO Journal - October 1, 2018 Category: Molecular Biology Authors: Tsuzuki, M., Wierzbicki, A. T. Tags: Chromatin, Epigenetics, Genomics & Functional Genomics, Plant Biology, RNA Biology News [amp ] Views Source Type: research