New model of marker placement to assess sagittal spine and lower limb during sit to stand: Typical kinematic pattern in LOPD

Introduction: Late onset Pompe disease (LOPD) is a neuromuscular disorder due to a mutation of the gene codifying lysosomal enzyme GAA, whose absence or deficiency causes a progressive accumulation of glycogen within lysosome and myofibrils that determines cardiac, respiratory and skeletal muscles alteration. The disease is characterized by primary involvement of trunk and pelvic girdle musculature that results in relevant ambulatory [1]. To the best of our knowledge only two studies assessed walking parameters in LOPD patients, finding similar spatial-temporal but heterogeneous kinematic and kinetic values [2].

Source: Gait and Posture - October 1, 2018 Category: Orthopaedics Authors: P. De Blasiis, S. Scarpetta, M. Sansone, M.A.B. Melone, Di Iorio, S. Sampaolo Source Type: research