Organotypic slice cultures of pancreatic ductal adenocarcinoma preserve the tumor microenvironment and provide a platform for drug response
/Objective: The conventional models currently used to evaluate various anti-tumor therapeutic agents are not sufficient for representing human pancreatic ductal adenocarcinoma (PDA), which has a unique tumor microenvironment. We aimed to produce an organotypic slice culture model from human PDA that resembles the in vivo situation and to evaluate the responses of PDA slices to established cytotoxic drugs.
Source: Pancreatology - Category: Gastroenterology Authors: Chae Yoon Lim, Jae Hyuck Chang, Won Sun Lee, Kang Min Lee, Young Chul Yoon, Jeana Kim, Il Young Park Source Type: research