Gene expression analysis of embryonic pancreas development master regulators and terminal cell fate markers in resected pancreatic cancer: A correlation with clinical outcome

Despite the recent introduction of new drugs and the development of innovative multi-target treatments, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains very poor. Even when PDAC is resectable, the rate of local or widespread disease recurrence remains particularly high. Currently, reliable prognostic biomarkers of recurrence are lacking. We decided to explore the potential usefulness of pancreatic developmental regulators as biomarkers of PDAC relapse.

Source: Pancreatology - October 4, 2018 Category: Gastroenterology Authors: Erica Dugnani, Valeria Sordi, Silvia Pellegrini, Raniero Chimienti, Ilaria Marzinotto, Valentina Pasquale, Daniela Liberati, Gianpaolo Balzano, Claudio Doglioni, Michele Reni, Alessandra Gandolfi, Massimo Falconi, Vito Lampasona, Lorenzo Piemonti Source Type: research