Effective inhibition of rifampicin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA polymerase inhibitor corallopyronin A

Rifampicin is highly active against various pathogenic bacteria, including Gram-negative, obligate intracellular Chlamydia trachomatis, which causes functional damage in female reproductive organs [1,2]. However, prolonged exposure to rifampicin causes mutations in the rpoB gene, resulting in the emergence of resistance in C. trachomatis in vitro [2]. In addition, we previously demonstrated that microenvironmental changes, such as different oxygen availabilities that can be found in female reproductive organs under physiological conditions, influence the efficacy of antimicrobials, including rifampicin [1].

Source: International Journal of Antimicrobial Agents - August 6, 2018 Category: Drugs & Pharmacology Authors: Kensuke Shima, Svea Ledig, Nathalie Loeper, Andrea Schiefer, Kenneth Pfarr, Achim Hoerauf, Simon Graspeuntner, Jan Rupp Tags: Letter to the Editor Source Type: research