First report of an mcr-1-harboring Salmonella enterica subsp. enterica serotype 4,5,12:i:- strain isolated from blood of a patient in Switzerland
In the past, colistin use has been mostly limited to veterinary medicine owing to its rather severe side effects, but given the increase in multidrug-resistant Gram-negative bacterial infections, the World Health Organization (WHO) recently re-labelled colistin as a ‘critically important antibiotic’. The first description of the plasmid-borne mobilizable colistin resistance gene mcr-1 in 2015 [1] caused great concern, as the ease of potential spread on a conjugative plasmid encoding resistance to polymyxins might change the resistance situation to colistin drastically.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Laura M. Carroll, Katrin Zurfluh, Hyein Jang, Gopal Gopinath, Magdalena N üesch-Inderbinen, Laurent Poirel, Patrice Nordmann, Roger Stephan, Claudia Guldimann Tags: Letter to the Editor Source Type: research