Insights into a novel Tn4401 deletion (Tn4401i) in a multidrug-resistant Klebsiella pneumoniae clinical strain belonging to the high-risk clonal group 258 producing KPC-2

In Brazil and other lower- and middle-income countries, the emergence and spread of high-risk clones of CTX-M-15- and KPC-2-producing Klebsiella pneumoniae has been observed in clinical settings at increasingly alarming frequencies [1,2]. The potential for global dissemination of resistance genes in K. pneumoniae is of concern because it is related to high-risk clones, i.e. clonal group 258 (CG258), and the presence of mobilised plasmids carrying Tn4401 [2].

Source: International Journal of Antimicrobial Agents - August 27, 2018 Category: Drugs & Pharmacology Authors: Bruna Fuga Ara újo, Sabrina Royer, Paola Amaral Campos, Melina Lorraine Ferreira, Iara Rossi Gonçalves, Luiz Gustavo Machado, Nilton Lincopan, Miriam Rodriguez Fernandes, Louise Teixeira Cerdeira, Deivid William da Fonseca Batistão, Paulo P. Gontijo-Fi Tags: Letter to the Editor Source Type: research