Resistance to fosfomycin: Mechanisms, Frequency and Clinical Consequences

Fosfomycin was discovered in 1969; it is a low molecular mass (138 Da) derivative of a phosphoric acid isolated from cultures of Streptomyces spp. (Streptomyces fradiae, Streptomyces viridochromogenes, and Streptomyces wedomorensis) [1-3]. It is also a product of a biosynthetic process after a unique combination of carbon and phosphorous [1,3]. When examining its actual structure, two key features can be found: an epoxide group, which is essential for its biologic activity and a phosphonic acid moiety.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research