Resistance to fosfomycin: Mechanisms, Frequency and Clinical Consequences
Fosfomycin was discovered in 1969; it is a low molecular mass (138 Da) derivative of a phosphoric acid isolated from cultures of Streptomyces spp. (Streptomyces fradiae, Streptomyces viridochromogenes, and Streptomyces wedomorensis) [1-3]. It is also a product of a biosynthetic process after a unique combination of carbon and phosphorous [1,3]. When examining its actual structure, two key features can be found: an epoxide group, which is essential for its biologic activity and a phosphonic acid moiety.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Matthew E. Falagas, Florentia Athanasaki, Georgios L. Voulgaris, Nikolaos A. Triarides, Konstantinos Z. Vardakas Tags: Review Source Type: research
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