Glucocorticoids suppress fibroblast apoptosis in an in vitro thermal injury model

In a cutaneous burn wound, there are three zones of thermal injury: the central zone of coagulation, the intermediate zone of stasis, and the outer zone of hyperemia [1]. Because the blood flow in the intermediate zone of stasis decreases naturally after thermal injury, removing the central zone of coagulation and performing immediate skin grafting is one way to rescue the zone of stasis [2]. Without treatment, the tissues in the zone of stasis will gradually die. This change is known as burn wound progression or conversion [3].

Source: Burns : Journal of the International Society for Burn Injuries - September 22, 2018 Category: Cosmetic Surgery Authors: Yoshitaka Matsuura, Kazuo Noda, Shigehiko Suzuki, Katsuya Kawai Source Type: research