The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome

Major burn injury induces a profound inflammatory response that in severe cases may lead to multiple organ failure and in some cases death [1]. Common clinical predictors of mortality following burn injury are burn extent, age, presence of inhalation injury and sepsis [2], but many other factors may have a large impact on outcome. The injury itself causes immediate and subsequent cell damage or death, inevitably giving rise to inflammatory cascade activation, as well as altered levels of glucagon, catecholamines and endogenous steroids [3 –5].

Source: Burns : Journal of the International Society for Burn Injuries - September 28, 2018 Category: Cosmetic Surgery Authors: Maria Bergquist, Johanna H ästbacka, Christian Glaumann, Filip Freden, Fredrik Huss, Miklos Lipcsey Source Type: research