Complete Resection Is Essential in the Surgical Treatment of Gestational Trophoblastic Neoplasia

Objective The aim of this study was to determine the utility of surgery in patients with gestational trophoblastic neoplasia (GTN). Materials and Methods We performed a retrospective institutional review board–approved analysis of all patients with GTN at a single institution from 1985 to 2015 and compared all patients who underwent surgery as definitive management for their disease to a matched cohort of those who did not. Kaplan-Meier curves were used to estimate progression-free survival (PFS) and overall survival (OS). Results Sixty-nine patients underwent a total of 94 surgeries as definitive treatment for GTN. Nineteen patients had multiple surgeries. Progression-free survival and OS were improved in patients with complete macroscopic surgical resection (n = 61) compared with patients with gross residual disease (n = 33) (median PFS 91.2 months vs 3.3 months, and median OS not reached at 108.8 months vs 66.3 months, respectively; P
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Gestational Throphoblastic Neoplasia Source Type: research