Early nonreactivity in the conjunctival provocation test predicts beneficial outcome of sublingual immunotherapy

ConclusionsUsing clinically meaningful outcome parameters during the pollen season, both trials independently led to similar results when comparing participants ’ reactions to the CPT 4 weeks after beginning SLIT. These results suggest that CPT allows an early estimation of allergic rhinoconjunctivitis symptoms before an upcoming season. Thus, the CPT can be used as a valuable parameter to predict the beneficial outcome of ongoing SLIT.Trial registrationBoth trials registered with the Medical Ethics Committee of the North Rhine Medical Council (EudraCT numbers 2012-004916-79 (grass pollen trial) and 2013-002129-43 (tree pollen trial)) and the German Federal Ministry of Health (Paul-Ehrlich-Institut).
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research