[18F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease

Neuroinflammation is associated with several neurological disorders, including Alzheimer's disease (AD). The translocator protein 18  kDa (TSPO), due to its overexpression during microglial activation and relatively low levels in the brain under normal neurophysiological conditions, is commonly used as an in vivo biomarker for neuroinflammation. Reported here is the preclinical evaluation of [18F]F-DPA, a promising new TSPO-spe cific radioligand, as a tool for the detection of activated microglia at different ages in the APP/PS1–21 mouse model of AD and a blocking study to determine the specificity of the tracer.

Source: Nuclear Medicine and Biology - September 26, 2018 Category: Nuclear Medicine Authors: Thomas Keller, Francisco R. L ópez-Picón, Anna Krzyczmonik, Sarita Forsback, Anna K. Kirjavainen, Jatta S. Takkinen, Obada Al-Zghool, Johan Rajander, Simo Teperi, Fanny Cacheux, Annelaure Damont, Frédéric Dollé, Juha O. Rinne, Olof Solin, Merja Haapa Source Type: research