Androgen treatment effects on hippocampus structure in boys with Klinefelter Syndrome

Klinefelter syndrome (KS) is a highly prevalent sex chromosome aneuploidy condition that affects up to 1 in 450 male births (Herlihy et al., 2011). The majority of affected males exhibit a 47,XXY karyotype, although more than one supernumerary X chromosome is sometimes observed (Rey et al., 2011, Boada et al., 2009). The physical phenotype typically includes tall stature, hypogonadism, reduced testosterone, infertility and gynecomastia. Features comprising the behavioral phenotype include mood symptoms and deficits in specific domains of cognitive function, predominantly language, learning and memory, and executive function (Boada et al., 2009, Ross et al., 2009).

Source: Psychoneuroendocrinology - October 1, 2018 Category: Psychiatry Authors: Lara C. Foland-Ross, Judith Ross, Allan L. Reiss Source Type: research