Association between baseline pro-inflammatory cytokines and brain activation during social exclusion in patients with vulnerability to suicide and depressive disorder

Inflammation and hypersensitivity to social rejection are both putative pathophysiological mechanisms in psychiatric illness. Growing evidences suggest the involvement of inflammation in mood disorders, and suicidal behaviors/vulnerability (Courtet et al., 2016). Two meta-analyses showed that basal blood inflammatory markers are increased during depressive episodes. Specifically, Dowlati et al. found that TNF- α and IL-6 are higher in depressed patients compared with healthy individuals (n = 24 studies included) (Dowlati et al., 2010).

Source: Psychoneuroendocrinology - October 4, 2018 Category: Psychiatry Authors: I Conejero, I. Jaussent, A. Cazals, E. Thouvenot, T. Mura, E. Le Bars, S. Guillaume, S. Squalli, P. Courtet, E. Oli é Source Type: research